You can manage cassandra.yaml from OpsCenter.
If the cluster exists in multiple datacenters, you can configure
cassandra.yaml for a single datacenter or for all nodes in
a cluster. To manage cassandra.yaml for a single node by
clicking on the Actions dropdown for a node.
Procedure
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Click Configure Cluster in any of the Cluster views.
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Edit the value for any of the options.
For a description of the options in the file, see the documentation for the
version of Cassandra or DSE which the cluster or node is running. For example,
cassandra.yaml.
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When finished editing, click Save.
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You will be prompted to perform a rolling restart on the nodes in your cluster,
or you may click Cancel if you do not wish to do a
restart.